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In Vitro Human Airway Models of Asthma and COPD ( MatTek )
 

 
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Tissue Engineered In Vitro

Human Airway Models of Asthma and COPD

 

주문은 최소 1개월전에 하셔야 합니다.

 

INTRODUCTION: Asthma and chronic obstructive pulmonary disease (COPD) are the two leading chronic respiratory diseases in the US. However, reliable in vitro human models are not widely available to researchers attempting to understand asthma and COPD pathogenesis and develop therapeutic interventions for these diseases. Here we report on a program to create and maintain a human cell bank derived from airway epithelium of diseased individuals, and production of tissue engineered in vitro human models of asthma and COPD from the cells.

 

  Technical References

(Asthma, COPD, Smoker )

 

Asthma

 

731. APPLICATION OF ORGANOTYPIC IN VITRO HUMAN CELL CULTURE MODELS FOR RESEARCH AND DEVELOPMENT OF INHALATION PHARMACEUTICAL FORMULATIONS TARGETING THE PROXIMAL AIRWAYS.

Hayden, P. MatTek Corporation, Ashland, MA. Inhalation Magazine (2012).

696. HISTAMINE MAY INDUCE AIRWAY REMODELING THROUGH RELEASE OF EPIDERMAL GROWTH FACTOR RECEPTOR LIGANDS FROM BRONCHIAL EPITHELIAL CELLS

Hirota1, N., Risse1, P.-A., Novali1, M., McGovern1, T., Al-Alwan1, L., McCuaig1, S., Proud2, D., Hayden, P., Hamid1, Q., and Martin, J. G. 1Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada; 2Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; and MatTek Corporation, Ashland, Massachusetts, USA. FASEB J. 26, 000–000 (2012).

663. MECHANISMS OF GOBLET CELL HYPERPLASIA INDUCED BY SIMULATED VIRAL EXPOSURE OR TH2 CYTOKINES.

Bolmarcich1, J., Wilbert2, S., Wright2, C., Jackson1, G.R., Kenney2, T., Baker2, B. and Hayden1, P. 1MatTek Corporation, Ashland, MA, USA. 2Gilead Sciences, Seattle, WA, USA. Presented at ATS Meeting, Denver, CO (2011).

641. LTD4 INDUCES HB-EGF-DEPENDENT CXCL8 RELEASE THROUGH EGFR ACTIVATION IN HUMAN BRONCHIAL EPITHELIAL CELLS.

McGovern, T., Risse, P-A., Tsuchiya, K., Hassan, M., Frigola, G., and Martin, J.G. Meakins-Christie Laboratories, Department of Medicine, McGill University, Montréal, Québec, Canada. Am J Physiol Lung Cell Mol Physiol, 299: L808–L815, 2010.

631. FILTER-WELL TECHNOLOGY FOR ADVANCED THREE-DIMENSIONAL CELL CULTURE: PERSPECTIVES FOR RESPIRATORY RESEARCH.

Berube1, K., Pitt2, A., Hayden3, P., Prytherch­1, Z. and Job1, C. 1School of Biosciences, Cardiff University, Cardiff, Wales, UK; 2Millipore Corporation, Danvers, MA, USA; 3MatTek Corporation, Ashland, MA, USA. ATLA, 38, Supplement 1, 49-65, (2010).

619. NOTCH SIGNALING PROMOTES AIRWAY MUCOUS METAPLASIA AND INHIBITS ALVEOLAR DEVELOPMENT.

Guseh1,2, J.S., Bores1,2, S.A., Stanger3, B.Z., Zhou1, Q., Anderson1, W.J., Melton1, D.A. and Rajagopal1,2, J. 1Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. 2Department of Internal Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. 3Division of Gastroenterology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Development 136, 1751-1759, 2009. Development 136, 1751-1759, 2009.

591. CIGARETTE SMOKE ALTERS TISSUE INHIBITOR OF METALLOPROTEINASE 1 AND MATRIX METALLOPROTEINASE 9 LEVELS IN THE BASOLATERAL SECRETIONS OF HUMAN ASTHMATIC BRONCHIAL EPITHELIUM IN VITRO.

Watson1,2, A.M., Benton1, A.S., Rose1,3,4,5, M.C. and Freishtat1,4,5,6, R.J. 1Research Center for Genetic Medicine, Children’s National Medical Center; 2Institute of Biomedical Sciences, and Departments of 3Biochemistry and Molecular Biology, 4Integrative Systems Biology, and 5Pediatrics, School of Medicine and Health Sciences, The George Washington University; and 6Division of Emergency Medicine, Children’s National Medical Center, Washington, DC. J Investig Med, 58, 725-729, 2010.

581. ASTHMATIC AIRWAY EPITHELIUM IS INTRINSICALLY INFLAMMATORY AND MITOTICALLY DYSSYNCHRONOUS.

Freishtat1,2,3, R.J., Watson3, A.M., Benton3, A.S., Iqbal1,2,3, S.F., Pillai1,3,4, D.K., Rose1,3, .M.C. and Hoffman1,3, E.P. 1Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences; 2Division of Emergency Medicine, Department of Pediatrics, George Washington University School of Medicine and Health Sciences; 3Center for Genetic Medicine Research, Children’s National Medical Center; and 4Division of Pulmonary Medicine, Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC. Am J Resp Cell Mol Biol, 44,863-869, 2011

570. TIMECOURSE OF TH2 CYTOKINE-INDUCED GOBLET CELL HYPERPLASIA IN THE EPIAIRWAY™ IN VITRO HUMAN AIRWAY MODEL.

Bolmarcich, J., Jackson, G.R. Jr., Klausner, M. and Hayden, P.J. MatTek Corporation, Ashland, MA. Presented at American Thoracic Society Meeting, New Orleans, 2010.

562. ESTABLISHMENT OF A 3D AIRWAY MODEL FOR RESPIRATORY INFECTION.

Published by Battelle Memorial Institute. (2010).

521. TISSUE ENGINEERED IN VITRO HUMAN AIRWAY MODELS (EPIAIRWAY) OF ASTHMA AND COPD.

Hayden, P.J., Jackson, Jr., G.R., Bolmarcich, J., and Klausner, M. MatTek Corporation, Ashland, MA. Presented at AAPS 2012.

509. ROLE OF TOLL-LIKE RECEPTOR (TLR) ACTIVATION IN ASTHMA EXACERBATION: EXPERIMENTS WITH IN VITRO MODELS OF HUMAN AIRWAY EPITHELIAL CELLS (EPIAIRWAY) AND EPITHELIAL CELL/FIBROBLAST CO-CULTURES (EPIAIRWAY-FT).

Hayden1, P.J., Bolmarcich1, J., Armento1, A., Jackson, Jr.1, G.R., Hackett2, T.L., Knight2, D.A. and Klausner1, M. 1 MatTek Corporation, Ashland, MA. 2 James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Vancouver, BC, Canada. Presented at American Thoracic Society Annual Meeting (2009).

484. CD137/CD137L EXPRESSION AND SIGNALING IN IN VITRO MODELS OF HUMAN AIRWAY EPITHELIUM, DENDRITIC CELLS AND T-CELLS.

Hayden, P.J., Ayehunie, S., Spiller, E., Snell, M., Jackson, G.R. Jr., and Klausner, M. MatTek Corporation, Ashland, MA. Amer. J. of Respiratory and Critical Care Medicine, Vol 177 (Abstracts Issue): pA72 (2008).

446. CYTOKINE-INDUCED GOBLET CELL HYPERPLASIA IN THE (EPIAIRWAY-FT) IN VITRO FULL-THICKNESS HUMAN AIRWAY MODEL.

Hayden, P.J., Jackson, G.R., Bolmarcich, J.L., Stolper, G., Spiller, E. and Klausner, M. MatTek Corporation, Ashland, MA, United States. Presented at the American Thoracic Society Annual Meeting, San Francisco, CA, May 22, Poster No. B33 (2007).

410. TH2 CYTOKINE STIMULATED AIRWAY EPITHELIAL CELLS DEMONSTRATE GRANULE-DEPENDENT FasL LOCALIZATION.

Singhera, G.K., Sekhon, M.S., Dorscheid, D.R. The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul’s Hospital / Providence Health Care-University of British Columbia, Vancouver, BC, Canada. Presented at the American Thoracic Society Annual Meeting, San Diego, CA., May 19-24 (2006).

370. MICROARRAY EXPRESSION STUDIES ON AN IN VITRO MODEL OF HUMAN AIRWAY EPITHELIUM (EPIAIRWAY).

Moffatt1, M.F., Hill1, A.L., Hao1, L., Taylor2, J., Hayden3, P.J., Cookson1, W.O.C.M. 1Wellcome Trust Centre for Human Genetics, University of Oxford, U.K; 2Department of Statistics, Oxford Centre for Gene Function, University of Oxford, U.K; 3MatTek Corporation, Ashland, MA, U.S.A. Presented at American Thoracic Society, San Diego, CA, May 20-25, (2005).

332. AN IN VITRO MODEL OF FULL-THICKNESS HUMAN AIRWAY EPITHELIUM (EPIAIRWAY-FT) FOR STUDY OF EPITHELIUM/MATRIX INTERACTIONS.

Hayden, P. J., Klausner, M., Kubilus, J., Burnham, B., Jackson, G. R. MatTek Corporation, Ashland, MA. Presented at the American Thoratic Society Meeting, Orlando, FL, May 21-26, (2004).

267. TUMOR NECROSIS FACTOR ALPHA (TNFα) INDUCTION OF THYMUS AND ACTIVATION REGULATED CHEMOKINE (TARC) EXPRESSION IS MEDIATED BY 15-LIPOXYGENASE 15-(LOX)-2 IN THE EPIAIRWAY™ HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL.

Jackson1, G.R., Last1, T.J., Klausner1, M., Kubilus1, J., Shappell2, S.B., Brash2, A.R. and Hayden1, P. 1MatTek Corporation, Ashland, MA USA, and 2Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN USA. Presented at the American Thoracic Society Meeting, Atlanta, GA, May (2002).

256. EXPRESSION OF 15-LIPOXYGENASE-2 IN THE EPIAIRWAY™ IN VITRO HUMAN TRACHEAL/BRONCHIAL EPITHELIAL MODEL: REGULATION BY TNF-α AND INF-γ.

Hayden1, P.J., Jackson1, G.R., Last1, T.J., Klausner1, M., Kubilus1, J., Shappell2, S.B. 1MatTek Corp., Ashland, MA, 2Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN. The Toxicologist, 66 (1-S), 100, Soc. of Toxicol. (Reston, VA), Abstract #486, (2002).

254. NEW PERSPECTIVES ON SKIN-COMPATIBLE DETERGENTS FOR SENSITIVE SKIN.

Kremer1, J., Matthies1, W. and Voigtmann2, I. 1Henkel KGaA, Henkelstr. 67, 40191 Dusseldorf. 2Deutscher Allergie- und Asthmabund e. V., Hindenburgstr. 110, 41061 Monchengladbach. 14th Lecture Conference of the GDCH Section "Waschmittelchemie", Wurzburg, Germany, April (2000).

242. CHARACTERIZATION OF INFLAMMATORY MEDIATOR RELEASE FROM AN IN VITRO HUMAN TRACHEAL/BRONCHIAL EPITHELIAL TISSUE MODEL.

Hayden, P., Jackson, R., Last, T.J., Klausner, M. and Kubilus, J. MatTek Corp., Ashland, MA 01721. The Toxicologist, 60 (1), 425, Soc. of Toxicol. (Reston, VA), Abstract #2023, (2001).

225. CHARACTERIZATION OF INFLAMMATORY MEDIATOR RELEASE FROM AN IN VITRO HUMAN BRONCHIAL/TRACHEAL EPITHELIAL TISSUE MODEL.

Hayden, P., Jackson, R., Klausner, M., Kubilus, J. MatTek Corp., Ashland, MA. Presented at the Lovelace Respiratory Research Institute International Symposium, Santa Fe, NM, October 3, (2000).

168. RECONSTRUCTED, DIFFERENTIATED AIRWAY EPITHELIAL CULTURES TO DETECT OCCUPATIONAL ASTHMA CAUSING AGENTS.

Sheasgreen, J., Klausner, M., Kubilus, J., Ogle, P. MatTek Corp., Ashland, MA. USA. The Toxicologist, 48 (1-S), 126, Soc. of Toxicology (Reston, VA), Abstract #594, (1999).

 

COPD

 

731. APPLICATION OF ORGANOTYPIC IN VITRO HUMAN CELL CULTURE MODELS FOR RESEARCH AND DEVELOPMENT OF INHALATION PHARMACEUTICAL FORMULATIONS TARGETING THE PROXIMAL AIRWAYS.

Hayden, P. MatTek Corporation, Ashland, MA. Inhalation Magazine (2012).

663. MECHANISMS OF GOBLET CELL HYPERPLASIA INDUCED BY SIMULATED VIRAL EXPOSURE OR TH2 CYTOKINES.

Bolmarcich1, J., Wilbert2, S., Wright2, C., Jackson1, G.R., Kenney2, T., Baker2, B. and Hayden1, P. 1MatTek Corporation, Ashland, MA, USA. 2Gilead Sciences, Seattle, WA, USA. Presented at ATS Meeting, Denver, CO (2011).

642. IN VITRO EXPOSURE OF ORGANOTYPICAL 3D EPITHELIAL TISSUES TO CIGARETTE SMOKE AS A POTENTIAL ALTERNATIVE TO RODENT INHALATION STUDIES.

Weisensee, D., Kurkowsky, B., Hebestreit, M., Wagner, S., and Schueller, J. Philip Morris Research Laboratories GmbH, Cologne, Germany. Presented at SOT 2011, Abstract #998.

570. TIMECOURSE OF TH2 CYTOKINE-INDUCED GOBLET CELL HYPERPLASIA IN THE EPIAIRWAY™ IN VITRO HUMAN AIRWAY MODEL.

Bolmarcich, J., Jackson, G.R. Jr., Klausner, M. and Hayden, P.J. MatTek Corporation, Ashland, MA. Presented at American Thoracic Society Meeting, New Orleans, 2010.

562. ESTABLISHMENT OF A 3D AIRWAY MODEL FOR RESPIRATORY INFECTION.

Published by Battelle Memorial Institute. (2010).

521. TISSUE ENGINEERED IN VITRO HUMAN AIRWAY MODELS (EPIAIRWAY) OF ASTHMA AND COPD.

Hayden, P.J., Jackson, Jr., G.R., Bolmarcich, J., and Klausner, M. MatTek Corporation, Ashland, MA. Presented at AAPS 2012.

446. CYTOKINE-INDUCED GOBLET CELL HYPERPLASIA IN THE (EPIAIRWAY-FT) IN VITRO FULL-THICKNESS HUMAN AIRWAY MODEL.

Hayden, P.J., Jackson, G.R., Bolmarcich, J.L., Stolper, G., Spiller, E. and Klausner, M. MatTek Corporation, Ashland, MA, United States. Presented at the American Thoracic Society Annual Meeting, San Francisco, CA, May 22, Poster No. B33 (2007).

370. MICROARRAY EXPRESSION STUDIES ON AN IN VITRO MODEL OF HUMAN AIRWAY EPITHELIUM (EPIAIRWAY).

Moffatt1, M.F., Hill1, A.L., Hao1, L., Taylor2, J., Hayden3, P.J., Cookson1, W.O.C.M. 1Wellcome Trust Centre for Human Genetics, University of Oxford, U.K; 2Department of Statistics, Oxford Centre for Gene Function, University of Oxford, U.K; 3MatTek Corporation, Ashland, MA, U.S.A. Presented at American Thoracic Society, San Diego, CA, May 20-25, (2005).

332. AN IN VITRO MODEL OF FULL-THICKNESS HUMAN AIRWAY EPITHELIUM (EPIAIRWAY-FT) FOR STUDY OF EPITHELIUM/MATRIX INTERACTIONS.

Hayden, P. J., Klausner, M., Kubilus, J., Burnham, B., Jackson, G. R. MatTek Corporation, Ashland, MA. Presented at the American Thoratic Society Meeting, Orlando, FL, May 21-26, (2004).

 

Smoker

 

663. MECHANISMS OF GOBLET CELL HYPERPLASIA INDUCED BY SIMULATED VIRAL EXPOSURE OR TH2 CYTOKINES.

Bolmarcich1, J., Wilbert2, S., Wright2, C., Jackson1, G.R., Kenney2, T., Baker2, B. and Hayden1, P. 1MatTek Corporation, Ashland, MA, USA. 2Gilead Sciences, Seattle, WA, USA. Presented at ATS Meeting, Denver, CO (2011).

642. IN VITRO EXPOSURE OF ORGANOTYPICAL 3D EPITHELIAL TISSUES TO CIGARETTE SMOKE AS A POTENTIAL ALTERNATIVE TO RODENT INHALATION STUDIES.

Weisensee, D., Kurkowsky, B., Hebestreit, M., Wagner, S., and Schueller, J. Philip Morris Research Laboratories GmbH, Cologne, Germany. Presented at SOT 2011, Abstract #998.

591. CIGARETTE SMOKE ALTERS TISSUE INHIBITOR OF METALLOPROTEINASE 1 AND MATRIX METALLOPROTEINASE 9 LEVELS IN THE BASOLATERAL SECRETIONS OF HUMAN ASTHMATIC BRONCHIAL EPITHELIUM IN VITRO.

Watson1,2, A.M., Benton1, A.S., Rose1,3,4,5, M.C. and Freishtat1,4,5,6, R.J. 1Research Center for Genetic Medicine, Children’s National Medical Center; 2Institute of Biomedical Sciences, and Departments of 3Biochemistry and Molecular Biology, 4Integrative Systems Biology, and 5Pediatrics, School of Medicine and Health Sciences, The George Washington University; and 6Division of Emergency Medicine, Children’s National Medical Center, Washington, DC. J Investig Med, 58, 725-729, 2010.

494. GENOMIC BIOMARKERS OF PULMONARY EXPOSURE TO TOBACCO SMOKE COMPONENTS.

Sexton, K., Balharry, D., and BéruBé, K.A. Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK. Pharmacogenetics and Genomics, 18, 853-860, (2008).

482. CELLULAR RESPONSES OF PRIMARY HUMAN BRONCHIAL EPITHELIAL CELLS TO WHOLE CIGARETTE SMOKE EXPOSURE.

Chalupowicz, D.G., Frankowski, R., Sanchez, Y., Kou, J., Barnette, M., and Walsh, P.T. GlaxoSmithKline. Amer. J. of Respiratory and Critical Care Medicine, Vol 177 (Abstracts Issue): pA199 (2008).

481. EXPOSURE OF A MULTI-CELLULAR IN VITRO MODEL OF HUMAN AIRWAY TISSUE TO WHOLE CIGARETTE SMOKE.

Walsh, P.T., Chalupowicz, D.G., Frankowski, R., Barnette, M. Discovery Biology, Respiratory CEDD, GlaxoSmithKline, Upper Merion, PA19406, USA. Amer. J. of Respiratory and Critical Care Medicine, Vol 177 (Abstracts Issue): pA728 (2008).

395. BENZO[A]PYRENE-INDUCED ORAL CARCINOGENESIS AND CHEMOPREVENTION – STUDIES IN BIOENGINEERED HUMAN TISSUE.

Walle1, T., Walle1, U.K., Sedmera2, D., Klausner3, M. 1Department of Cell and Molecular Pharmacology and Experimental Therapeutics, University of South Carolina, Charleston; 2Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston; 3MatTek Corporation, Ashland, Massachusetts. Drug Metabolism and Disposition, 2006 34: 346-350.

359. IDENTIFICATION OF INTELLIGENT BIOMARKERS OF EXPOSURE AND HARM IN THE RESPIRATORY EPITHELIAL TO TOBACCO SMOKE COMPONENTS.

BéruBé, K., Sexton, K., Jones, T. School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3US, Wales, UK.

 

 

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