STD Infection ( EpiVaginal )

The Model

To facilitate the study of vaginal-ectocervical (VEC) toxicity, pathologies, and basic mucosal phenomena, MatTek has developed the EpiVaginal series of tissue models. EpiVaginal tissues are based on normal, human-derived VEC epithelial and dendritic cells (DC). All VEC tissues are cultured on specially prepared cell culture inserts and are multilayered and highly differentiated. The tissues closely parallel native human tissues, thus providing a useful in vitro means to assess toxicity, sexually transmitted infections, and other basic vaginal phenomena. For more information on EpiVaginal, click here.

Technical References

685. ANTI-GP120 MINIBODY GENE TRANSFER TO FEMALE GENITAL EPITHELIAL CELLS PROTECTS AGAINST HIV-1 VIRUS CHALLENGE IN VITRO. Abdel-Motal¹, U.M., Sarkis¹, P.T.N., Han¹, T., Pudney², J., Anderson², D.J., Zhu¹, Q., Marasco¹, W.A.  ¹Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, ²Department of Obstetrics and Gynecology, School of Medicine, Boston University, Boston, Massachusetts, United States of America.

671. PREVENTION OF VAGINAL SHIV TRANSMISSION IN MACAQUES BY A LIVE RECOMBINANT LACTOBACILLUS. Lagenaur^1,2, L.A., Sanders-Beer³, B.E., Brichacek¹, B., Pal⁴, R., Liu², X. Liu², Y., Yu⁵, R., Venzon⁶, D., Lee², P.P., and Hamer¹, D.H.  ¹Gene Structure and Regulation Section, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. ²Osel, Mountain View, California, USA. ³BIOQUAL, Rockville, Maryland, USA. ⁴Advanced BioScience Laboratories, Rockville, Maryland, USA. ⁵Cepheid, Sunnyvale, California, USA. ⁶Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA. Mucosal Immunology, advance online publication 6 July 2011, doi:10. 10.8/mi.2011.30

664. TRANSFER OF IgG IN THE FEMALE GENITAL TRACT BY MHC CLASS I-RELATED NEONATAL FC RECEPTOR (FCRN) CONFERS PROTECTIVE IMMUNITY TO VAGINAL INFECTION. Li^1,2, Z.,Palaniyandi^1,2, S., Zeng^1,2, R.,Tuo³, W., Roopenian⁴, D.C., and Zhu^1,2, X.  ¹Laboratory of Immunology, Virginia-Maryland Regional College of Veterinary  Medicine, College Park, MD 20742; ²Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742; ³Animal Parasitic Diseases Laboratory, Agricultural Research Service, United  States Department of Agriculture, Beltsville, MD 20705; and ⁴The Jackson Laboratory, Bar Harbor, ME 04609. PNAS, 108, (11), 4388-4393, (2011).

571. A NEW MODEL FOR STUDIES ON CERVICOVAGINAL INFLAMMATION AND BARRIER DISRUPTION. Blaskewicz1, C., Ayehunie2, S. and Anderson1, D. 1Boston University School of Medicine, Boston MA; 2MatTek Corp, Ashland, MA. Presented at Microbicide 2010 Conference, May 22-25, Pittsburg, PA.

430. TRICHOMONAS VAGINALIS LIPOPHOSPHOGLYCAN TRIGGERS A SELECTIVE UPREGULATION OF CYTOKINES BY HUMAN FEMALE REPRODUCTIVE TRACT EPITHELIAL CELLS. Fichorova¹, R., Trifonova¹, R., Gilbert², R., Costello³, C., Hayes⁴, G., Lucas⁴, J., and Singh⁴, B. ¹Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; ²Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY; ³Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA; and ⁴Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY. Infection and Immunity, 74, 10, 5773–5779, October (2006)

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