Inflammation ( EpiVaginal )
The Model
To facilitate the study of vaginal-ectocervical (VEC) toxicity, pathologies, and basic mucosal phenomena, MatTek has developed the EpiVaginal series of tissue models. EpiVaginal tissues are based on normal, human-derived VEC epithelial and dendritic cells (DC). All VEC tissues are cultured on specially prepared cell culture inserts and are multilayered and highly differentiated. The tissues closely parallel native human tissues, thus providing a useful in vitro means to assess toxicity, sexually transmitted infections, and other basic vaginal phenomena. For more information on EpiVaginal, click here.
Technical References
656. EPIVAGINAL TISSUE MODEL FOR PRECLINICAL SCREENING OF SINGLE OR REPEAT EXPOSURE TO VAGINALLY APPLIED CHEMICALS/FORMULATIONS. Ayehunie, S., Cannon, C., LaRosa, K., Landry, T., Wang, A., and Klausner, M. MatTek Corporation, Ashland, MA, USA. Presented at SOT 2011, Abstract #1049.
639. ASSESSMENT OF ORGANOTYPIC EPIVAGINALTM TISSUE MODEL TO SCREEN IRRITATION POTENTIAL OF CHEMICALS. Ayehunie, S., Kaluzhny, Y., Cannon, C., LaRosa, K., Klausner, M. MatTek Corporation, Ashland, MA. Presented at 49th Annual SOT Meeting, Salt Lake City, Utah (2010).
571. A NEW MODEL FOR STUDIES ON CERVICOVAGINAL INFLAMMATION AND BARRIER DISRUPTION. Blaskewicz1, C., Ayehunie2, S. and Anderson1, D. 1Boston University School of Medicine, Boston MA; 2MatTek Corp, Ashland, MA. Presented at Microbicide 2010 Conference, May 22-25, Pittsburg, PA
555. PSORIASIN (S100A7) IS A MAJOR ANTIMICROBIAL COMPONENT OF THE FEMALE GENITAL TRACT. Mildner1, M., Abtin1, A., Gmeiner1, R., Sam1, C., Gläser2, R., Schröder2, J-M., Mlitz1, V., Stichenwirth1, M., Pammer1, J., Geusau1, A., Tschachler1, E. 1Medical University of Vienna, Vienna, Austria 2University Hospital Schleswig-Holstein, Kiel, Germany. 37th Annual Meeting of the European Society for Dermatological Research, 5-8 September 2007, Zurich, Switzerland.
469. STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL. Anderson1, D., Nadolski1, A., Xu1, C., Pudney1, J., Politch1, J., Viglianti1, G., Bowman1, F., Ayehunie2, S., and Klausner2, M. 1Boston University School of Medicine, Boston, MA and 2MatTek Corporation, Ashland, MA. Microbicides 2008.
